After completing some Nioh 3 Myths in Warring Stateswill players be able to deal with Headache Myth is accepted from Tokugawa Ieyasu. While talking to him on top of Hamamatsu Castlehe will mention that he needs medicine because he has a terrible headache and wants the player to check out the village of Futamata road. Here is a complete walkthrough for this side quest Nioh 3.
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Nioh 3 headache myth guide
Once you make it to the village, deal with any enemies you come across nearby and head into one of the houses to find a corpse to loot. Search the body to get Crafting Guide: Ghostly Call. This is not the medicine itself but only the recipe for it, so you can now go back to Hamamatsu Castle.
At the castle, go to the top and talk to Hattori Hanzowho will be at Ieyasu's side. He will mention that the headache is still there, and some Yokai have appeared inside the castle.
After this conversation, go down to find Nuppeppo at the castle gate. When it detects you, it will start rolling away and for now, all you have to do is chase it until it reaches a dead end. On the far side of the castle, when it reaches a wall, it will now become hostile to you, and a boss fight will begin.
You can fight the boss with either style, depending on how many skill points and hours you've put into either. Most of the boss's attacks are pretty easy to deflectso the Samurai style can make this boss easy. Once the boss is dealt with it will drop Yokai Gallstone.
Take this gallstone to the Rift and go to the blacksmith. Here you have the opportunity to Forging toolsand a new recipe will be added for you to create. Crafts Ghostly conversation and go back to Hamamatsu Castle and give the medicine to complete this quest.


- Released
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February 6, 2026
- ESRB
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Mature 17+ / Blood and Gore, Suggestive Themes, Violence, In-Game Purchases, User Interaction